Persantine use as an anti-platelet vs. Plavix and Coumadin

[Gemmasmom]

Does anyone have any experience with them or their child using Persantine as an anti-platelet drug? My daughter, Gemma, acquired KD almost 17 months ago and has been on aspirin, Lovenox, and Trenal since then and we hoping to get her off Lovenox in the next few months. Both her current Cardiologist here in Houston and Dr. Newburger believe she should be on dual anti-platelet drugs moving forward, and we are looking the options.

Apirin and Persantine
Apirin and Plavix
Apirin and Coumadin

I would love any feedback from patients or parent of patients who are on any type of similar regimen.

My daughter had extensive coronary damage (multiple giant aneurysms) in all three coronaries. Her aneurysms have regressed, but her RCA developed a clot and completely clotted off. She now has some collateral vessels that have developed in lieu of a RCA and less than ideal Left Circumflex as well. This is why she needs the anti-coagulation to prevent another clot.

[Momcat]

Paige's cardiologist initially wanted her on persantine (which I thought was Plavix......maybe it isn't--)........I'm not sure why he changed his mind, but I think it may have had something to do with the long afterlife of coumadin in the bloodstream-it lasts for up to 3 days--longer than the other med. This would be helpful (and has been) since sometimes she forgets to take it on time and occasionally misses a dose. I can't imagine keeping a child on Lovenox for so long---injections or does she have a port? Those injections are painful!

[jem65]

I am new to this forum hence the delay replying to your reply. My son too has giant and large aneuryms. When he was first diagnosed(3 yrs old) he was on aspirin and persantin for 6 months. He was then changed to Plavix and aspirin. That was in 2000. He remained on this combination for about five years clot free. We moved to the US during this time and we were constantly being told that coumadin and aspirin were the standard drugs of choice but the cardiologist at the time was ok leaving him on the Plavix . We were relectant to change because our son has a severe severe needle phobia and we knew that changing to coumadin would require frequent blood tests .Long story short, Drs. leave, new Dr arrives and wants our son on coumadin and aspirin. We got the INR home testing machine which has lessened the needle trauma slightly. I believe the difference in all these drugs is how the interfere with the clotting process. Coumadin intereferes with Vitamin K, Plavix intereferes with platlet formation. I know that Dr. Jane Burns( San Diego) prefers Coumadin and Aspirin . Hope this is of some help

[fouz]

hi
my daughter too has a giant aneurysm,when she was diagnosis with kd we went to france for medical care (we lived in the middle east)
and there they recommend her to have her in aspirine and coumadine she is on it since july2009 and we check her at the clinic once a month
we just have too watch what she is eating cause coumadine interfer with vitamine k too much of it (vitamine k) can change her irn level in her blood
best of luckxx

[trevsmom]

My son takes aspirin and coumadin because of his 2 giant aneurysms.
My understanding (from a non-medical professional, just a mom listening to the doc. talk in the office) is that the two meds work on different parts of the clotting process. Aspirin is a platelet inhibitor (as is Plavix), and coumadin/warfarin works against vitamin K to keep clots from forming.